' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 44 Researches
7.6
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Teaspoon (5 ml)
Amount Per Serving
%DV
Calories
40
Total Fat
4.5 g
6%**
Saturated Fat
0.5 g
3%**
Cholesterol
15 mg
5%
Vitamin A (from cod liver oil and retinyl palmitate)
255 mcg RAE(850 IU)
28%
Vitamin D (from cod liver oil and cholecalciferol)
10 mcg (400 IU)
50%
Vitamin E (as d-alpha tocopherol)
6.7 mg
45%
Norwegian Cod Liver Oil
4.6 g
†
Total Omega-3 Fatty Acids*
1,100 mg
†
DHA (Docosahexaenoic Acid)*
500 mg
†
EPA (Eicosapentaenoic Acid)*
370 mg
†
DPA (Docosapentaenoic Acid)*
50 mg
†
Top Medical Research Studies
9
DHA-PS promotes liver recovery
DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis.
Highly relevant to liver health
We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.
Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.
Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.
Read More
9
DHA's Role in Liver Health
Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury.
Study highlights DHA's importance
We explored the impact of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on the health of our liver, especially regarding nonalcoholic fatty liver disease (NAFLD). Using a zebrafish model with a specific mutation that prevents the production of DHA, we aimed to understand how this absence affects liver lipid balance and overall liver health.
Our findings revealed that without sufficient DHA, the liver showed increased fat storage and issues with fat processing. Instead of breaking down fats as it should, the liver was overwhelmed with lipids, leading to the telltale signs of NAFLD. Additionally, we noted that the liver cells in our mutated model were suffering from structural damage and stress, primarily through a process known as ferroptosis—rather than the more commonly known apoptosis.
Interestingly, when we supplemented these fish with DHA through diet or genetic modifications, we observed a remarkable improvement in liver health. This suggests that maintaining proper levels of DHA is crucial for preventing fatty liver disease and protecting liver cells from damage.
Our findings revealed that without sufficient DHA, the liver showed increased fat storage and issues with fat processing. Instead of breaking down fats as it should, the liver was overwhelmed with lipids, leading to the telltale signs of NAFLD. Additionally, we noted that the liver cells in our mutated model were suffering from structural damage and stress, primarily through a process known as ferroptosis—rather than the more commonly known apoptosis.
Interestingly, when we supplemented these fish with DHA through diet or genetic modifications, we observed a remarkable improvement in liver health. This suggests that maintaining proper levels of DHA is crucial for preventing fatty liver disease and protecting liver cells from damage.
Read More
9
DPA protects against liver disease
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Strong evidence for DPA's benefits
We observed how docosapentaenoic acid (DPA) supplementation can impact liver health in mice fed a high-fat diet. The study involved 4-month-old male C57BL/6J mice, where it was found that those on a high-fat diet showed signs of fatty liver, obesity, and insulin resistance after just six weeks. However, when they were given DPA, interesting changes occurred.
The results revealed that DPA not only prevented the development of fatty liver but also kept serum cholesterol and glucose levels in check. It significantly improved insulin resistance, which was not the case for eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Additionally, DPA helped maintain healthy levels of a hormone called adiponectin, which is crucial for metabolic health.
Furthermore, DPA supplementation also reduced increased liver enzyme levels, suggesting fewer inflammation and damage to the liver. These impressive benefits seem to stem from DPA's unique ability to influence important pathways in the liver that control fat production and inflammation.
Overall, it appears that DPA stands out in providing liver protection against the negative effects of a high-fat diet, making it a noteworthy contender in the fight against liver disease.
The results revealed that DPA not only prevented the development of fatty liver but also kept serum cholesterol and glucose levels in check. It significantly improved insulin resistance, which was not the case for eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Additionally, DPA helped maintain healthy levels of a hormone called adiponectin, which is crucial for metabolic health.
Furthermore, DPA supplementation also reduced increased liver enzyme levels, suggesting fewer inflammation and damage to the liver. These impressive benefits seem to stem from DPA's unique ability to influence important pathways in the liver that control fat production and inflammation.
Overall, it appears that DPA stands out in providing liver protection against the negative effects of a high-fat diet, making it a noteworthy contender in the fight against liver disease.
Read More
Most Useful Reviews
9.5
Promising recovery
To be honest, it is excellent in all its flavours. I ordered it a month ago to address my liver disease and related stomach issues. My immunity is low, and my weight has drastically dropped. Since using it, I’ve felt better, and I’ve started eating more. I will continue to buy it until I am fully healed. It assists in healing, but if the taste is too strong, one can use empty capsules, filling them and storing them properly. I wish for a speedy recovery for all.
Read More
9.5
Pain relief achieved
After breaking both my feet, I developed arthritis, and since starting cod liver oil three months ago, it has reduced most of the pain. I feel generally better and more active now, which is a relief.
Read More
8.8
Improved condition
I’ve been taking Carlson cod liver oil for over two weeks as my doctor recommended it for my dry eyes, and it has really helped. My mother, who suffered from vitamin D deficiency and felt weak, started using it for a month and has noticed significant improvement. It’s a quality product that I’m quite pleased with.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 44 Researches
7.6
9
Cod liver oil protects liver health
Cod liver oil in sodium nitrite induced hepatic injury: does it have a potential protective effect?
Study closely relates to liver disease
We examined the effects of cod liver oil on liver inflammation caused by sodium nitrite, a common food additive known for its harmful effects at high levels. In this study, we treated thirty-two adult male rats with sodium nitrite and observed the potential protective role of cod liver oil.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
The rats received either sodium nitrite alone or sodium nitrite along with cod liver oil. We assessed liver damage through various markers and tissue staining. The results indicated that cod liver oil significantly reduced liver cell damage. Furthermore, it helped lower levels of inflammatory cytokines and markers associated with tissue fibrosis and cell death compared to the group that received sodium nitrite alone.
Our findings suggest that cod liver oil can play a beneficial role in protecting the liver from inflammation and injury caused by sodium nitrite exposure. This highlights the potential of dietary interventions in managing liver health.
Read More
9
Cod liver oil protects liver health
Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats.
Highly relevant to liver disease
We explored how cod liver oil may help protect the liver from damage caused by sodium nitrite, a substance known for its harmful effects. Thirty-two male rats were used in our study, where some received sodium nitrite alone while others were treated with both sodium nitrite and cod liver oil.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
After treatment, we examined the liver sections for any changes and measured markers indicating oxidative stress and liver function. Our findings showed that cod liver oil significantly reduced harmful liver enzymes, preventing liver cell damage.
Additionally, we observed that cod liver oil lowered levels of oxidative stress indicators and improved mitochondrial function, which are crucial for liver health. It also reduced inflammation and DNA damage caused by sodium nitrite.
Overall, the study suggests that dietary cod liver oil can be beneficial in combating liver damage linked to sodium nitrite exposure through several protective mechanisms.
Read More
9
DHA combined with MCTs beneficial
Cosupplementation with DHA and medium-chain triglycerides ameliorates NAFLD and reduces amyloid-β accumulation by modulating hepatic lipid metabolism in APP/PS1 mice.
Moderately relevant due to combination
We explored the effects of docosahexaenoic acid (DHA) on liver disease, specifically looking at its role in nonalcoholic fatty liver disease (NAFLD) and its potential connection to Alzheimer's disease. Our study conducted on APP/PS1 mice involved four groups of animals fed different diets—one with DHA, one with medium-chain triglycerides (MCTs), and one that combined both treatments.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Throughout the study, which lasted eight months, we observed a significant reduction in blood and liver lipids in the group that received both DHA and MCTs. This combination not only alleviated signs of NAFLD but also reduced the buildup of amyloid-β (Aβ), a protein linked to Alzheimer's, in the brain and serum.
Additionally, our findings indicated that DHA combined with MCTs improved the activity of liver enzymes critical for lipid metabolism. This suggests that these compounds together may enhance the liver's ability to clear fat and cholesterol while also increasing Aβ clearance.
While we noted the benefits of DHA, it's important to remember that the effects we observed were influenced by the combination with MCTs, making it challenging to pinpoint DHA's isolated impact. Still, our research provides valuable insight into how enhancing dietary fats could support liver health and potentially mitigate connections to neurodegenerative diseases.
Read More
9
Docosahexaenoic acid for liver cancer
APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage.
Examines DHA effectiveness in therapy
We explored the effectiveness of docosahexaenoic acid (DHA), particularly when delivered via nanoparticles, in treating liver disease, specifically hepatocellular carcinoma (HCC), in three rodent models. Our focus was on understanding how DHA affects HCC lesions as well as the performance of weighted amide proton transfer (APT) MRI as a monitoring tool.
In all three models—diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft—the APT MRI revealed higher signals from the cancerous tissue compared to surrounding normal tissue. Notably, in the DEN model, we found that the APT signal could effectively differentiate between malignant lesions and benign nodules.
After administering LDL-DHA nanoparticles directly into tumors, we observed a rapid decrease in APT signals within 72 hours, suggesting a promising therapeutic response. This trend was consistent in both N1S1 and HepG2 xenografts, indicating that DHA's effects, accelerated by nanoparticles, hold potential for therapeutic applications in liver cancer management.
Overall, our findings underscore the utility of APT imaging in the diagnostic and therapeutic landscapes of HCC, showcasing how innovative delivery methods can enhance treatment outcomes.
In all three models—diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft—the APT MRI revealed higher signals from the cancerous tissue compared to surrounding normal tissue. Notably, in the DEN model, we found that the APT signal could effectively differentiate between malignant lesions and benign nodules.
After administering LDL-DHA nanoparticles directly into tumors, we observed a rapid decrease in APT signals within 72 hours, suggesting a promising therapeutic response. This trend was consistent in both N1S1 and HepG2 xenografts, indicating that DHA's effects, accelerated by nanoparticles, hold potential for therapeutic applications in liver cancer management.
Overall, our findings underscore the utility of APT imaging in the diagnostic and therapeutic landscapes of HCC, showcasing how innovative delivery methods can enhance treatment outcomes.
Read More
9
Nutrient cocktail improves liver health
Use of a Micronutrient Cocktail to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Adults with Obesity: A Randomized, Double-Blinded Pilot Clinical Trial.
Mixed nutrient effects observed
We conducted a study to understand how a specific mix of nutrients, including docosahexaenoic acid, impacts liver health in adults suffering from metabolic dysfunction-associated steatotic liver disease (MASLD) due to obesity. This involved a carefully controlled pilot clinical trial where participants were either given a nutrient cocktail or a placebo over three months.
The results were quite promising. Those who received the nutrient cocktail had notable reductions in liver fat content and fibrosis as indicated by improvements in their liver scans. Specifically, we observed an average reduction of 4% in the controlled attenuation parameter (CAP) and 7.8% in transient elastography (TE) scores among the treatment group.
Although docosahexaenoic acid was part of this nutrient blend, the study didn't isolate its effects. Therefore, while the overall findings suggest that such a supplementation might enhance liver health, the individual contribution of docosahexaenoic acid remains unclear. This points towards a need for more targeted research to fully understand its role in treating liver conditions.
The results were quite promising. Those who received the nutrient cocktail had notable reductions in liver fat content and fibrosis as indicated by improvements in their liver scans. Specifically, we observed an average reduction of 4% in the controlled attenuation parameter (CAP) and 7.8% in transient elastography (TE) scores among the treatment group.
Although docosahexaenoic acid was part of this nutrient blend, the study didn't isolate its effects. Therefore, while the overall findings suggest that such a supplementation might enhance liver health, the individual contribution of docosahexaenoic acid remains unclear. This points towards a need for more targeted research to fully understand its role in treating liver conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Promising recovery
To be honest, it is excellent in all its flavours. I ordered it a month ago to address my liver disease and related stomach issues. My immunity is low, and my weight has drastically dropped. Since using it, I’ve felt better, and I’ve started eating more. I will continue to buy it until I am fully healed. It assists in healing, but if the taste is too strong, one can use empty capsules, filling them and storing them properly. I wish for a speedy recovery for all.
Read More
9.5
Pain relief achieved
After breaking both my feet, I developed arthritis, and since starting cod liver oil three months ago, it has reduced most of the pain. I feel generally better and more active now, which is a relief.
8.8
Improved condition
I’ve been taking Carlson cod liver oil for over two weeks as my doctor recommended it for my dry eyes, and it has really helped. My mother, who suffered from vitamin D deficiency and felt weak, started using it for a month and has noticed significant improvement. It’s a quality product that I’m quite pleased with.
Read More
8.8
Healthy improvement
Carlson is my long-awaited find for heart and skin health. The fat from wild Norwegian cod liver is a genuine source of Omega-3. After regular use, I've noticed improvements in energy and well-being. I recommend it as a high-quality natural supplement for those looking to enhance their diet.
Read More
5.5
Joint support noted
Cod liver oil was recommended to me for my eyes and joints, and as a senior, it has indeed aided my joints. I'm still able to ride my bike in nice weather. I take a teaspoon daily, and on stressful days, I double the dosage.
